934291

Thalidomide-O-amido-C₈-NH₂ trifluoroacetate

≥95.0%

• Synonym(s): N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate
• Empirical Formula (Hill Notation): C₂₃H₃₀N₄O₆·C₂HF₃O₂
• CAS Number: 1950635-16-1
• Molecular Weight: 572.53
• UNSPSC Code: 12352200
• NACRES: NA.21

Properties

• ligand: thalidomide
• Quality Level: 100
• assay: ≥95.0%
• form: powder or crystals
• storage temp.: 2-8°C
• SMILES string: O=C(C(F)(F)F)[O-].O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCC[NH3+]

Description

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H312,H360D
• pcodes: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable