933562
NanoFabTx™ - Synthetic Folate Lipid Mix
for synthesis of folate functionalized liposomes for targeted delivery
Synonym(s):
Cholesterol, Drug delivery, Folate-PEG-DSPE, Hydro Soy PC, LNP, Microfluidics, NanoFab reagent kit, Nanoformulation, Nanoparticle, PE-PEG
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About This Item
Recommended Products
Quality Level
storage temp.
−20°C
Application
NanoFabTx™ Synthetic Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
The NanoFabTx™ Synthetic Folate Lipid mix includes a lyophilized lipid blend containing rationally selected lipids that has been optimized to synthesize folate-functionalized liposomes of a desired size range. The synthesized folate-functionalized liposomes enable selectively targeting cells which overexpressed folate-receptors (e.g., HeLa cells) and delivery both hydrophilic and hydrophobic drugs.
The NanoFabTx™ Synthetic Folate Lipid mix includes a lyophilized lipid blend containing rationally selected lipids that has been optimized to synthesize folate-functionalized liposomes of a desired size range. The synthesized folate-functionalized liposomes enable selectively targeting cells which overexpressed folate-receptors (e.g., HeLa cells) and delivery both hydrophilic and hydrophobic drugs.
Features and Benefits
- A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes
- Step-by-step extrusion and microfluidics protocols developed and tested by our formulation scientists
- Flexible synthesis methods to create uniform and reproducible liposomes
- Protocols and lipid blend optimized to synthesize liposomes around 100 nm with low polydispersity
- Lipid mix optimized for folate-functionalized liposomes for small molecule encapsulation
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
TMAX is a trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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International journal of nanomedicine, 16, 683-700 (2021-02-05)
To develop an externally triggered rapid-release targeted system for treating ovarian cancer, gemcitabine (GMC) was entrapped into sonosensitive (SoS) folate (Fo)-modified liposomes (LPs). GMC-loaded LPs (GMC LPs), GMC-loaded Fo-targeted LPs (GMC-Fo LPs), and GMC-loaded Fo-targeted SoS LPs (GMC-SoS Fo LPs)
Signal transduction and targeted therapy, 5(1), 6-6 (2020-04-17)
Tumor-associated macrophages (TAMs) facilitate cancer progression by promoting tumor invasion, angiogenesis, metastasis, inflammatory responses, and immunosuppression. Folate receptor β (FRβ) is overexpressed in TAMs. However, the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood. In this study
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