Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

902659

Sigma-Aldrich

Amino-PEG6-t-butyl ester

Synonym(s):

tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate, H2N-PEG6-CH2CH2COOtBu

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H39NO8
CAS Number:
1286281-32-0
Molecular Weight:
409.51
MDL number:
MFCD13184944
UNSPSC Code:
51171641
NACRES:
NA.22

form

liquid

reaction suitability

reagent type: cross-linking reagent

refractive index

n/D 1.4562

density

1.06581 g/mL

functional group

amine
ester

storage temp.

−20°C

SMILES string

NCCOCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

InChI

1S/C19H39NO8/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h4-17,20H2,1-3H3

InChI key

QGSFECNPSLZGGT-UHFFFAOYSA-N

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Judit Erchegyi et al.
Journal of medicinal chemistry, 59(3), 854-866 (2016-01-21)
CRF mediates numerous stress-related endocrine, autonomic, metabolic, and behavioral responses. We present the synthesis and chemical and biological properties of astressin B analogues {cyclo(30-33)[D-Phe(12),Nle(21,38),C(α)MeLeu(27,40),Glu(30),Lys(33)]-acetyl-h/r-CRF(9-41)}. Out of 37 novel peptides, 17 (2, 4, 6-8, 10, 11, 16, 17, 27, 29, 30
Minoru Ueda et al.
Chemistry, an Asian journal, 6(12), 3286-3297 (2011-08-05)
Affinity chromatography by using ligand-immobilized bead technology is generally the first choice for target exploration of a bioactive ligand. However, when a ligand has comparatively low affinity against its target, serious difficulties will be raised in affinity-based target detection. We
Minoru Ueda et al.
Bioorganic & medicinal chemistry letters, 21(5), 1359-1362 (2011-02-08)
Affinity purification using immunoprecipitation (IP) is an extremely useful method for target profiling of bioactive natural products. We examined IP purification of CMetE, which is a molecular target for potassium isolespedezate (1), a leaf-opening factor of Cassia plant. We studied
Efficient synthesis of small-sized phosphonated dendrons: potential organic coatings of iron oxide nanoparticles
Garofalo A, et al.
New. J. Chem. (2014)
Radiolabeled dendritic probes as tools for high in vivo tumor targeting: application to melanoma
Parat A, et al.
Journal of Material Chemistry B: Materials for Biology and Medicine (2015)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service