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Key Documents

901361

Sigma-Aldrich

N-((Methylsulfonyl)oxy)acetimidoyl chloride

≥95%

Synonym(s):

(1-Chloroethylidene)azanyl ester methanesulfonic acid

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About This Item

Empirical Formula (Hill Notation):
C3H6ClNO3S
CAS Number:
Molecular Weight:
171.60
UNSPSC Code:
12352101

Quality Level

assay

≥95%

form

powder or crystals

functional group

amine
chloro
sulfonic acid

Application

This air- and moisture-stable reagent enables the direct functionalization of pyridines under mild conditions for late-stage diversification of complex and drug-like molecules.

Storage Class

4.1B - Flammable solid hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Patrick S Fier
Journal of the American Chemical Society, 139(28), 9499-9502 (2017-07-06)
Herein is reported the design and application of a reagent for the direct functionalization of pyridines. These reactions occur under mild conditions and exhibit broad functional group tolerance, enabling the late-stage functionalization of drug-like molecules. The reagent can be easily

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