805092

PLGA nanoparticles

100 nm average diameter

• Synonym(s): Degradex^® PLGA, poly(D,L-lactide-co-glycolide)
• Linear Formula: HO(C₃H₄O₂)_x(C₂H₂O₂)_yH
• UNSPSC Code: 12162002
• NACRES: NA.23

Properties

• form: powder
• Quality Level: 100
• average diameter: 100 nm
• density: 1.3 g/cm³
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

Degradex^® is made with poly(D,L-lactide-co-glycolide) with an L/G ratio of 50/50 and a Mw of 30,000.
To re-constitute:

• Remove the product from freezer.
• Wait until temperature rises to the ambient temperature.
• Add DI water or buffer to the container.
• Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended.

The particle size of the PLGA nanoparticles are closely dependent on both the nature and concentration of the stabilizer and polymer.

Application

Plain PLGA particles can be used for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery.A study reports the use of PLGA nanoparticles as estrogen carriers. The carrier-drug system was prepared by emulsification-diffusion method.

Legal Information

Degradex is a registered trademark of Phosphorex, Inc.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable