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746118

Sigma-Aldrich

Sodium difluoroheptylazidosulfinate

95%

Synonym(s):
Sodium 7-azido-1,1-difluoroheptanesulfinate, Baran DAAS-Na Reagent, Sodium 1,1-difluoro-7-azido-heptylsulfinate
Empirical Formula (Hill Notation):
C7H12F2N3NaO2S
CAS Number:
Molecular Weight:
263.24
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

95%

form

solid

reaction suitability

reagent type: catalyst
reaction type: C-H Activation

reagent type: linker

storage temp.

2-8°C

SMILES string

[Na+].[O-]S(=O)C(F)(F)CCCCCCN=[N+]=[N-]

InChI

1S/C7H13F2N3O2S.Na/c8-7(9,15(13)14)5-3-1-2-4-6-11-12-10;/h1-6H2,(H,13,14);/q;+1/p-1

InChI key

FFNHIEJQAMGBCZ-UHFFFAOYSA-M

Application

Within heteroarene platforms, DAAS-Na allows for the direct introduction of a difluoroalkyl chain carrying an azide group, which is designed for the purpose of bioconjugation. Through a Huisgen cycloaddition (a "click" reaction), the azide moiety can then be reacted with a terminal alkyne that is bound to a functional molecule such as biomacromolecules. This effectively allows for a covalent linkage between a heteroarene and any target molecule, for example, between a heteroarene-containing drug and an antibody. This reagent was developed by the Baran Group and is one of several reagents for the direct alkylation of heterocycles.

Learn More at the Professor and Product Portal of Professor Phil S. Baran.

Packaging

100 mg in glass insert

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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More Documents

Quotes and Ordering

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