741949

Sigma-Aldrich

Gold nanoparticles

5 nm diameter, OD 1, stabilized suspension in citrate buffer

Synonym(s):
Au NP, Gold Colloid
Linear Formula:
Au
Molecular Weight:
196.97
MDL number:
PubChem Substance ID:
NACRES:
NA.23

Quality Level

form

nanoparticles
suspension

contains

stabilizer (Proprietary Surfactant)

concentration

~5.5E+13 particles/mL

OD

1

diameter

5 nm

λmax

510-525 nm

PDI

<0.2

storage temp.

2-8°C

SMILES string

[Au]

InChI

1S/Au

InChI key

PCHJSUWPFVWCPO-UHFFFAOYSA-N

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General description

Gold nanoparticles (AuNPs) are colloidal nanoparticles with multiple surface functionalities that can be used in the development of new biomaterials. AuNP has a spherical structure with a large surface to volume ratio and excellent biocompatibility. It is majorly used in a variety of biomedical applications ranging from diagnostics to drug delivery.

Packaging

25, 100 mL in poly bottle

Application

Ideal for adsorption of thiolated ligands such as oligonucleotides and polyethylene glycols. Also, due to the increased stability, these gold nanoparticles are ideal for use in physical and optical applications. Note: This product is not ideal for protein adsorption. For gold nanoparticles suitable for adsorption of proteins and other ligands for conjugate development, please see our gold nanoparticles stabilized in PBS.

This material is highly monodisperse (<12% variability in size and shape), and provides significantly improved surface reactivity. Applications include Surface Enhanced Raman Lables, Sensing/Detection, Biological Targeting, Plasmonics and Electronics.

Legal Information

Product of CytoDiagnostics, Inc.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What is the shape of the gold nanoparticles?

    The majority (>95%) of the gold nanoparticles are spherical.

  7. Can the Gold nanoparticles be frozen?

    No, the Gold nanoparticles should not be frozen.  If frozen, the gold nanoparticles will irreversibly aggregate, turning the solution clear.

  8. Which gold nanoparticle size should I choose for my application?

    The size of gold nanoparticle to use is very depandent upon the intended application. Generally, smaller particles offer better sensitivity in applications such as immunogold labeling due to less steric hindrance and the ability to bind more gold nanoparticles to the desired target. Small gold nanoparticles are less visible than larger particles, however, which must also be taken into account.As an application example, particles with a size between 30-50nm are particularly useful for the development of rapid tests such as lateral flow assays.

  9. My gold nanoparticles settle out of solution upon storage. Is this normal?

    Settling of gold nanoparticles on the bottom of the storage flask is completely normal and is especially common for larger sized particles, which settles at greater speed. Settling does not affect the performance of the particles. Prior to use, simply swirl the solution to properly disperse your gold nanoparticles and obtain a homogenous solution.

  10. Why does my gold nanoparticle solution turn violet when I add salt containing buffer?

    Due to repulsive forces arising from the surface charge of gold nanoparticles, an energy barrier must be overcome for individual particles to interact. When no (or small) amounts of electrolytes such as NaCl is present, this energy barrier is too strong for interaction to occur between particles. However, upon addition of NaCl this energy barrier is reduced allowing the gold nanoparticles to interact and aggregate. This aggregation causes a phenomenon called surface-plasmon coupling which changes the adsorption maximum of light to a higher wavelength resulting in a change in color of the solution.

Gold nanoparticles: synthesis and applications in drug delivery
Khan AK, et al.
Tropical Journal of Pharmaceutical Research, 13(7), 1169-1177 (2014)
Gold nanoparticles: preparation, properties, and applications in bionanotechnology
Yeh Y, et al.
Nanoscale, 4(6), 1871-1880 (2012)
Articles
Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.
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Gold (Au) nanoparticles have tunable optical and electronic properties and are used in a number of applications including photovoltaics, sensors, drug delivery & catalysis.
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Gold (Au) nanoparticles have tunable optical and electronic properties and are used in a number of applications including photovoltaics, sensors, drug delivery & catalysis.
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