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717142

Sigma-Aldrich

Poly(ethylene glycol) dithiol

average Mn 1,000, thiol

Synonym(s):

Polyethylene glycol, PEG dithiol

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About This Item

Linear Formula:
HSCH2CH2(OCH2CH2)nSH
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) dithiol, average Mn 1,000

form

solid

mol wt

average Mn 1,000

reaction suitability

reagent type: cross-linking reagent
reactivity: thiol reactive

mp

29-33 °C

Ω-end

thiol

α-end

thiol

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

2-8°C

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Application

Thiol functionalized nanoparticles may be used in mucoadhesive drug delivery, synthesis of dithiol terminated amphiphilic diblock copolymer, Bidentate dithiol-poly(ethylene glycol)-poly(d,l-lactide) (SH2-PEG-PDLLA). Gold nanoparticles may be easily functionalized with PEG dithiols by simple ligand exchange.

Other Notes

Molecular weight: Mn 900-1,100

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Nadeau J
Introduction to Experimental Biophysics: Biological Methods for Physical Scientists null
Jian Yang et al.
Biomacromolecules, 15(4), 1346-1354 (2014-03-13)
Thiol-modified nanoparticles have potential applications in mucoadhesive drug delivery and have been examined in this regard for topical ocular delivery. In this paper we provide a simple method for the synthesis of a dithiol terminated amphiphilic diblock copolymer. Bidentate dithiol-poly(ethylene

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Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

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