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656682

Sigma-Aldrich

Chloromethyl chlorosulfate

97%

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About This Item

Linear Formula:
ClCH2OSO2Cl
CAS Number:
49715-04-0
Molecular Weight:
165.00
EC Number:
256-442-1
MDL number:
MFCD00041547
UNSPSC Code:
12352100
PubChem Substance ID:
24884216
NACRES:
NA.22

Quality Level

100

assay

97%

refractive index

n20/D 1.448

bp

45-50 °C/10 mmHg

density

1.631 g/mL at 25 °C

functional group

chloro

storage temp.

2-8°C

SMILES string

ClCOS(Cl)(=O)=O

InChI

1S/CH2Cl2O3S/c2-1-6-7(3,4)5/h1H2

InChI key

PJBIHXWYDMFGCV-UHFFFAOYSA-N

Application

Reagent for chloromethylation of Fmoc-protected amino acids without the generation of carcinogenic bis(chloromethyl)ether.

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 4 Oral - Carc. 1A - Skin Corr. 1B

Storage Class

5.1B - Oxidizing hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ5288
MKCK7152
MKCC5620
MKBX2332V

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Nicholas P Power et al.
Organic & biomolecular chemistry, 2(10), 1554-1562 (2004-05-12)
The reaction of liquid (gamma-) SO3 with CH2Cl2 at room temperature leads to SO3 insertion into the C-Cl bonds, giving the useful chloromethylating agent chloromethyl chlorosulfate (CMCS). The process is very slow but becomes rapid on addition of catalytic quantities

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