540285
Tetraalkylammonium carbonate, polymer-bound
macroporous, 18-50 mesh, extent of labeling: 2.5-3.5 mmol/g N loading
Synonym(s):
MP-carbonate resin
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About This Item
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form
macroporous
reaction suitability
reaction type: solution phase peptide synthesis
reactivity: proton reactive
extent of labeling
2.5-3.5 mmol/g N loading
particle size
18-50 mesh
SMILES string
[O-]C([O-])=O.C=Cc1ccccc1.C=Cc2ccc(C=C)cc2.CC[N+](CC)(CC)Cc3ccccc3.CC[N+](CC)(CC)Cc4ccccc4
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General description
Tetraalkylammonium carbonate, polymer-bound also known as MP-carbonate resin, is a strong basic macroporous anion-exchange polystyrene resin that is commonly used in solution phase peptide synthesis and resin-based purification techniques.
Application
Tetraalkylammonium carbonate, polymer-bound, is used as a solid support base in the solution phase parallel synthesis of amides to remove unwanted acidic by-products. It is used as a solid-phase base to neutralize the hydrobromide in the synthesis of syringolin B.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Solution-phase parallel synthesis of 5-carboxamido 1-benzyl-3-(3-dimethylaminopropyloxy)-1H-pyrazoles as activators of soluble guanylate cyclase with improved oral bioavailability
DL Selwood, et.al.
Bioorganic & Medicinal Chemistry Letters, 11, 1089-1092 (2001)
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