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Quality Level
assay
95%
form
solid
mp
158-161 °C (lit.)
functional group
anhydride
ester
fluoro
SMILES string
Fc1cccc2C(=O)OC(=O)c12
InChI
1S/C8H3FO3/c9-5-3-1-2-4-6(5)8(11)12-7(4)10/h1-3H
InChI key
WWJAZKZLSDRAIV-UHFFFAOYSA-N
General description
3-Fluorophthalic anhydride undergoes reduction with NaBH4 to afford 4-fluorophthalide and 7-fluorophthalide. It can be synthesized starting from 3-nitrophthaloyl dichloride.
Application
3-Fluorophthalic anhydride may be used in the preparation of substituted benzamides with potential neuroleptic activity. It may be employed as starting reagent for the synthesis of 8-fluoro-10-methyl-1,2-benzanthracene.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Synthesis of 8-Fluoro-10-methyl-1, 2-benzanthracene1.
The Journal of Organic Chemistry, 26(9), 3208-3211 (1961)
A new synthesis of 3-fluorophthalic anhydride.
Journal of Fluorine Chemistry, 50(2), 251-255 (1990)
Regioselectivity of metal hydride reductions of unsymmetrically substituted cyclic anhydrides. systems where" steric hindrance along the preferred reaction path" rationalization is not applicable.
Canadian Journal of Chemistry, 58(23), 2484-2490 (1980)
Notes-Preparation of 3-Fluorophthalic Anhydride.
The Journal of Organic Chemistry, 25(5), 834-835 (1960)
Journal of medicinal chemistry, 39(5), 1172-1188 (1996-03-01)
A series of substituted (4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)benzamide derivatives was prepared and evaluated as potential atypical antipsychotic agents. The target compounds were readily prepared from their benzoyl chloride, benzoic acid, or isatoic anhydride precursors, and they were evaluated in vitro for their ability
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