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446424

Sigma-Aldrich

3,5-Di-tert-butyl-4-hydroxybenzyl alcohol

97%

Synonym(s):

3,5-Di-tert-butyl-4-hydroxyphenylmethanol, 4-Hydroxymethyl-2,6-di-tert-butylphenol

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About This Item

Linear Formula:
HOC6H2[C(CH3)3]2CH2OH
CAS Number:
88-26-6
Molecular Weight:
236.35
EC Number:
201-815-6
MDL number:
MFCD00017254
UNSPSC Code:
12352100
PubChem Substance ID:
24868276
NACRES:
NA.22

assay

97%

form

solid

mp

139-141 °C (lit.)

SMILES string

CC(C)(C)c1cc(CO)cc(c1O)C(C)(C)C

InChI

1S/C15H24O2/c1-14(2,3)11-7-10(9-16)8-12(13(11)17)15(4,5)6/h7-8,16-17H,9H2,1-6H3

InChI key

HNURKXXMYARGAY-UHFFFAOYSA-N

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Application

3,5-Di-tert-butyl-4-hydroxybenzyl alcohol can be used as a reactant to synthesize:      
  • 2,6-di-tert-butyl-4-(dodecylselanylmethyl)phenol and bis(3,5-di-tert-butyl-4-hydroxybenzyl) selenide by reacting with dodecaneselenolate and sodium selenide.      
  • Monomeric antioxidant by reacting with imidazole and N-[4-(chlorocarbonyl)phenyl]maleimide.     
  • Sulfur-containing butylated hydroxytoluene derivatives by reacting with aryl/alky dithiols.      
  • 3,5-Di-tert-butyl-4-hydroxybenzaldehyde by oxidation reaction using stabilized IBX.

hcodes

H412

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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O L Brekke et al.
Cytokine, 4(4), 269-280 (1992-07-01)
The effect of commonly used food antioxidants on recombinant tumor necrosis factor alpha (rTNF-alpha)-induced cytotoxicity, growth enhancement and adhesion has been evaluated. Butylated hydroxyanisole (BHA) and 4-hydroxymethyl-2,6-di-t-butylphenol (HBP) were the only two of nine antioxidants that completely inhibited rTNF-alpha-induced cytotoxicity
L R Barclay et al.
Biochimica et biophysica acta, 1328(1), 1-12 (1997-08-14)
Phenolic antioxidants of the hydroxychroman class, alpha-tocopherol (alpha-TOC) and 2,2,5,6,7-pentamethyl-6-hydroxychroman (PMHC), and the hindered phenols 2,3-dihydro-5-hydroxy-2,2,4-trimethylnaphtho[1,2-b]furan (NFUR), 2,6-di-tert-butyl-4-methoxyphenol (DBHA), and 2,6-di-tert-butyl-4-methyl phenol (BHT), were delivered into oxidizable (ACCEPTOR) liposomes of dilinoleoylphosphatidylcholine (DLPC) or 1-palmitoyl-2-linoleoyl-phosphatidylcholine (PLPC) from saturated DONOR liposomes of
REACTION OF SEVEN-AND EIGHT-MEMBERED CYCLIC PHOSPHOROCHLORIDITES WITH 3, 5-DI-tert-BUTYL-4-HYDROXYBENZYL ALCOHOL: FACILE P [sbnd] C BOND FORMATION.
Odorisio PA, et al.
Phosph. Sulfur Relat. Elem., 20(3), 273-277 (1984)
The antioxidant activity of 3, 5-di-tert-butyl-4-hydroxybenzyl derivatives.
Kim DH and Kummerow FA.
Journal of the American Chemical Society, 39(3), 150-155 (1962)
Synthesis of new polymeric antioxidants.
Oh DR, et al.
Bull. Korean Chem. Soc., 22(6), 629-632 (2001)
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