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About This Item
Linear Formula:
HOC6H4OCH2CO2H
CAS Number:
Molecular Weight:
168.15
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
assay
98%
mp
154-157 °C (lit.)
SMILES string
OC(=O)COc1ccc(O)cc1
InChI
1S/C8H8O4/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4,9H,5H2,(H,10,11)
InChI key
PKGWLCZTTHWKIZ-UHFFFAOYSA-N
General description
(4-Hydroxyphenoxy)acetic acid along with formaldehyde ammonium salt forms a polyaromatic anionic compound RG-13577. RG-13577 mimics the synthetic heparin and specifically binds to the vascular smooth muscle cells (SMCs) and inhibits their proliferative growth. In the molecules of (4-hydroxyphenoxy)acetic acid, the carboxyl groups are held together by R22(8) hydrogen bonds.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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(4-Hydroxyphenoxy) acetic acid.
Byres M and Cox PJ.
Acta Crystallographica Section E, Structure Reports Online, 63(6), o2931-o2931 (2007)
Yun-Loung Lin et al.
Bioorganic & medicinal chemistry letters, 12(13), 1709-1713 (2002-06-18)
An epoxybenzoquinone, 4-hydroxyphenoxypropionic acid, and 2-hydroxy-3-phenyl-3-butenoic acid derivatives have been designed, synthesized, and evaluated for in vitro inhibition activity against 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) from pig liver by the spectrophotometric enol-borate method. The biological data demonstrated that neither epoxybenzoquinone ester nor
M Benezra et al.
Journal of cellular biochemistry, 81(1), 114-127 (2001-02-17)
A synthetic heparin-mimicking polyaromatic anionic compound RG-13577 (polymer of 4-hydroxyphenoxy acetic acid and formaldehyde ammonium salt, Mr approximately 5800) exhibits specific binding to vascular smooth muscle cells (SMCs) and inhibits their proliferative response to growth promoting factors. Receptor binding of
B Palotás et al.
Analytical biochemistry, 179(2), 288-290 (1989-06-01)
A fast and sensitive spectrophotometric method has been developed to measure the level of hydroxylated by-products (p-hydroxyphenoxyacetic acid and p-hydroxypenicillin V) in penicillin V fermentations. The method is based on a color reaction of the above-mentioned phenolic by-products with nitrous
Choolakadavil Khalid Najeeb et al.
Colloids and surfaces. B, Biointerfaces, 102, 95-101 (2012-09-26)
Individual dispersion of single-walled carbon nanotubes (SWNTs) in biocompatible media is of particular interest for diverse biomedical and nanomedicine applications. Herein we present, for the first time, a neutral pH water-soluble chitosan derivative, chitosan-hydroxyphenyl acetamide (CHPA), prepared by functionalizing the
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