330477

1-(2-Hydroxyethyl)-2-pyrrolidone

98%

• Synonym(s): 1-(β-Hydroxyethyl)-2-pyrrolidone, 1-(2-Hydroxyethyl)-2-oxopyrrolidine, 2-(2-Oxopyrrolidin-1-yl)ethanol, 2-Hydroxyethylpyrrolidin-2-one, N-(β-Hydroxyethyl)-2-pyrrolidinone, N-(2-Hydroxyethyl)-2-pyrrolidinone
• Empirical Formula (Hill Notation): C₆H₁₁NO₂
• CAS Number: 3445-11-2
• Molecular Weight: 129.16
• Beilstein/REAXYS Number: 112181
• EC Number: 222-359-4
• MDL number: MFCD00014103
• UNSPSC Code: 12352100
• PubChem Substance ID: 24859862
• NACRES: NA.22

Properties

• assay: 98%
• form: liquid
• refractive index: n20/D 1.496 (lit.)
• bp: 140-142 °C/3 mmHg (lit.)
• density: 1.143 g/mL at 25 °C (lit.)
• SMILES string: OCCN1CCCC1=O
• InChI: 1S/C6H11NO2/c8-5-4-7-3-1-2-6(7)9/h8H,1-5H2
• InChI key: WDQFELCEOPFLCZ-UHFFFAOYSA-N

Description

General description

1-(2-Hydroxyethyl)-2-pyrrolidone serves as a versatile heterocyclic building block in the synthesis of pharmaceutical compounds.

Application

1-(2-Hydroxyethyl)-2-pyrrolidone (HEP) can be used as a starting material for the preparation of chemical intermediates such as 1-vinylpyrrolidinone , 1-[2-(diethylamino)ethyl]-2-pyrrolidinone , 1-(2-bromoethyl)-2-pyrrolidinone.
It can also be used as a building block in the synthesis of hexakis[2-(2-oxo-1-pyrrolidinyl)ethoxy]cyclotriphosphazene by a nucleophilic substitution reaction with hexachlorocyclotriphosphazene.

1-(2-Hydroxyethyl)-2-pyrrolidone may be used in chemical synthesis.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: 212.0 °F - closed cup
• flash_point_c: 100 °C - closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter