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223867

Sigma-Aldrich

Tolylene-2,6-diisocyanate

97%

Synonym(s):

2-Methyl-m-phenylene diisocyanate

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About This Item

Linear Formula:
CH3C6H3(NCO)2
CAS Number:
91-08-7
Molecular Weight:
174.16
Beilstein/REAXYS Number:
2211546
EC Number:
202-039-0
MDL number:
MFCD00002010
UNSPSC Code:
12162002
PubChem Substance ID:
24853409
NACRES:
NA.23

assay

97%

form

liquid

autoignition temp.

>1148 °F

refractive index

n20/D 1.571 (lit.)

bp

129-133 °C/18 mmHg (lit.)

density

1.225 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

Cc1c(cccc1N=C=O)N=C=O

InChI

1S/C9H6N2O2/c1-7-8(10-5-12)3-2-4-9(7)11-6-13/h2-4H,1H3

InChI key

RUELTTOHQODFPA-UHFFFAOYSA-N

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 2

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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B W Day et al.
Chemical research in toxicology, 9(3), 568-573 (1996-04-01)
Guinea pig hemoglobin (Hb) adducts of 2,4- and 2,6-toluene diisocyanate (2,4- and 2,6-TDI) were individually prepared, each at a Hb tetramer to diisocyanate ratio of 1:1, and compared with adducts of Hb from animals exposed to 1 ppm 2,4-TDI vapor.
S Mattoli et al.
The American journal of physiology, 259(4 Pt 1), L320-L327 (1990-10-01)
Bronchial epithelial cells release chemotactic factors for lymphocytes and express HLA-DR antigens. Thus they may contribute to the T-cell-mediated inflammatory responses involved in a number of pulmonary diseases such as asthma. In this study, the in vitro exposure of human
P Maestrelli et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 24(1), 29-34 (1994-01-01)
To assess the nature and the time-course of the cellular component of airway inflammation induced by isocyanates, we examined nine subjects with occupational asthma induced by toluene- or methylene diphenyl-diisocyanate (TDI, MDI) and four control subjects never exposed to isocyanates.
Sébastien Gagné et al.
The Analyst, 128(12), 1447-1451 (2004-01-23)
Isocyanates can cause occupational asthma. By using available HPLC-UVF methods, isocyanates can be quantified only at levels above 1% of the Permissible Exposure Limits (PEL). Once sensitized, workers can react to concentrations below these limits of detection (LOD) making these
G Sesana et al.
American Industrial Hygiene Association journal, 52(5), 183-186 (1991-05-01)
A new sampling system is presented that uses solid sorbent media contained in a tube for the determination of airborne isocyanates (2.4-2.6 toluene diisocyanate, hexamethylene diisocyanate, and 4.4' diaminodiphenylmethane diisocyanate). The method is compared with the National Institute for Occupational
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