16772

Cyanogen bromide

≥98.5% (RT)

• Synonym(s): Bromine cyanide
• Linear Formula: BrCN
• CAS Number: 506-68-3
• Molecular Weight: 105.92
• Beilstein/REAXYS Number: 1697296
• EC Number: 208-051-2
• MDL number: MFCD00011597
• UNSPSC Code: 12352100
• PubChem Substance ID: 57647589
• NACRES: NA.22

Properties

• vapor density: 3.65 (vs air)
• Quality Level: 200
• vapor pressure: 100 mmHg ( 22.6 °C)
• assay: ≥98.5% (RT)
• form: crystals
• bp: 61-62 °C (lit.)
• mp: 50-53 °C (lit.)
• functional group: bromo
• storage temp.: 2-8°C
• SMILES string: BrC#N
• InChI: 1S/CBrN/c2-1-3
• InChI key: ATDGTVJJHBUTRL-UHFFFAOYSA-N

Description

Application

• Cyanogen bromide is widely used in protein immobilization and cleavage.
• Under von Braun reaction conditions, CNBr reacts with tertiary amines to yield respective organocyanamides.
• It can also be used to synthesize organic intermediates like cyanuric bromide, derivatives of urea, guanidine, creatine, aryl nitriles, and a variety of heterocyclic compounds.

Other Notes

Reagent for the selective cleavage of peptide bonds (e.g. methionine)

Safety Information

• pictograms: GHS06,GHS05,GHS09
• signalword: Danger
• hcodes: H300 + H310 + H330,H314,H400
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B
• supp_hazards: EUH032
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: >149.0 °F - closed cup
• flash_point_c: > 65 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges