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Merck
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重要文件

V8261

Sigma-Aldrich

(±)-Vigabatrin

同義詞:

(R,S)-4-氨基-5-己烯酸, (±)-γ-乙烯基-GABA, (±)-4-氨基己酸

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About This Item

經驗公式(希爾表示法):
C6H11NO2
CAS號碼:
分子量::
129.16
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

起源

Lundbeck

SMILES 字串

NC(CCC(O)=O)C=C

InChI

1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)

InChI 密鑰

PJDFLNIOAUIZSL-UHFFFAOYSA-N

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生化/生理作用

不可逆的 GABA 转氨酶抑制剂。增加神经末梢的胞内 GABA 浓度;具有抗癫痫活性。

特點和優勢

《受体分类和信号转导手册》的GABA 转运蛋白GABAA 受体谷氨酸/GABA合成与代谢页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处
该化合物由Lundbeck开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

STOT RE 1

標靶器官

Eyes,Central nervous system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, has recently been reported to affect convulsant activity in some animal models of seizures and epilepsy. Moreover, its influence on the protective activity of some antiepileptic drugs (AEDs) was also noted. The aim
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Tuberous sclerosis complex is a multisystem genetic disorder. Epilepsy is very common in tuberous sclerosis and occurs in 75-92% of affected individuals during their life-time. Onset usually occurs during childhood and up to one third of children with tuberous sclerosis
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Journal of child neurology, 28(3), 308-313 (2012-07-04)
Tuberous sclerosis complex is a genetic disorder resulting in epilepsy and mental retardation. Vigabatrin has shown efficacy in the treatment of infantile spasms caused by tuberous sclerosis complex, but its effects on focal seizures caused by tuberous sclerosis complex have

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

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