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V113

Sigma-Aldrich

S(+)-γ-Vigabatrin

solid

同義詞:

S(+)-γ-Vinyl GABA, S(+)-4-Aminohexenoic acid

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About This Item

經驗公式（希爾表示法）:
C6H11NO2
CAS號碼:
74046-07-4
分子量：:
129.16
MDL號碼:
MFCD00274076
分類程式碼代碼:
12352200
PubChem物質ID:
24900710
NACRES:
NA.77

形狀

solid

品質等級

100

光學活性

[α]/D +11.8°, c = 2.5 in H2O(lit.)

顏色

off-white

溶解度

H2O: >20 mg/mL
ethanol: soluble

儲存溫度

2-8°C

SMILES 字串

N[C@@H](CCC(O)=O)C=C

InChI

1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m1/s1

InChI 密鑰

PJDFLNIOAUIZSL-RXMQYKEDSA-N

應用

S(+)-γ-Vigabatrin has been used as a standard in ultra-high-performance-liquid-chromatography (UHPLC).

生化／生理作用

γ-Vigabatrin has the potential to treat infantile spasms and seizures. It exhibits therapeutic effects against cocaine and other addictions.
GABA transaminase inhibitor; anti-convulsant.

注意

吸湿

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H372

危險分類

STOT RE 1

儲存類別代碼

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析證明 (COA)

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M M Robin et al.
European journal of pharmacology, 62(4), 319-327 (1980-04-04)
Unilateral intrastriatal injection of various substances induces a characteristic dyskinetic syndrome in rats. These substances include picrotoxin as well as a series of irreversible GABA-transaminase inhibitors. Using the degree of enzyme inhibition in various brain areas as a measure of
O M Larsson et al.
Neuropharmacology, 25(6), 617-625 (1986-06-01)
A preferential effect of valproate on gamma-aminobutyric acid (GABA) in the nerve terminal compartment has been proposed. Gamma-vinyl GABA, an irreversible inhibitor of GABA-transaminase (GABA-T) causes a preferential increase in the GABA compartment of the non-nerve terminal. The aim of
Evaluating risks for vigabatrin treatment
Krauss, Gregory L
Epilepsy currents, 9(5), 125-129 (2009)
Determination of enantiomeric vigabatrin by derivatization with diacetyl-l-tartaric anhydride followed by ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry
Zhao J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1040(5), 199-207 (2017)

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