5.05989

Vigabatrin

• 同義詞: Vigabatrin, 4-Amino-5-hexenoic acid, GABA Transaminase Inhibitor, Vigabatrin, γ-Vinyl-GABA, Sabril
• 經驗公式（希爾表示法）: C₆H₁₁NO₂
• CAS號碼: 68506-86-5
• 分子量：: 129.16
• MDL號碼: MFCD00274577
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥99% (HPLC)
• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: H₂O: 100 mM
• 儲存溫度: 2-8°C
• InChI: 1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
• InChI 密鑰: PJDFLNIOAUIZSL-UHFFFAOYSA-N

描述

一般說明

A selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC₅₀ = 2.9 mM)

生化／生理作用

Primary Target
GABA Transaminase

Reversible: no

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Abbot, E.L., et al. 2006. Br. J. Pharmacol.147, 298.
Schmid, L., et al. 1996. J. Pharmacol. Exp. Therap.276, 977.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H372
• 防範說明: P260 - P264 - P270 - P314 - P501
• 危險分類: STOT RE 1
• 儲存類別代碼: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable