T9772

三唑仑

• 同義詞: 8-Chloro-6-[2-chlorophenyl]-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
• 經驗公式（希爾表示法）: C₁₇H₁₂Cl₂N₄
• CAS號碼: 28911-01-5
• 分子量：: 343.21
• EC號碼: 249-307-3
• MDL號碼: MFCD00079623
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24900602
• NACRES: NA.77

屬性

• 藥物控制: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• 溶解度: 0.1 M HCl: soluble 1 g in 600 mL solvent; chloroform: soluble 1 g in 25 mL solvent; ethanol: soluble 1 g in 1000 mL solvent; DMSO: soluble 5.4 mg/mL; dichloromethane: 50 mg/mL, clear, colorless to faintly yellow; methanol: soluble 8.8 mg/mL; H₂O: insoluble; diethyl ether: insoluble
• 起源: Johnson & Johnson
• SMILES 字串: ClC1=CC=CC=C1C2=NCC3=NN=C(C)N3C4=CC=C(Cl)C=C42
• InChI: 1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
• InChI 密鑰: JOFWLTCLBGQGBO-UHFFFAOYSA-N
• 基因資訊: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

描述

應用

Triazolam has been used to define nonspecific binding in radioligand binding assays. Triazolam has also been used to study the effects of reducing mPer1 mRNA levels in mouse cerbellum.

生化／生理作用

Anxiolytic; ligand for the GABA_A receptor benzodiazepine modulatory site.

特點和優勢

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

準備報告

Triazolam is soluble in dichloromethane at 50 mg/ml, with heat as needed, yielding a clear, colorless to faint yellow solution. Furthermore, 1g of triazolam is soluble in 25 mL chloroform, 1000 mL ethanol, and 600 mL 0.1 M HCl. It is also soluble in DMSO (5.4 mg/ml) and methanol (8.8 mg/ml). However, it is insoluble in water and in ether.

安全資訊

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H361fd
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)