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Key Documents

SML3677

Sigma-Aldrich

Cryosim-3

≥98% (HPLC)

同義詞:

1-Di(isopropyl)phosphinoyl-nonane, 1-Diisopropylphosphorylnonane, Bis(1-methylethyl)nonylphosphine oxide, DIPA 1-9

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About This Item

經驗公式(希爾表示法):
C15H33OP
CAS號碼:
分子量::
260.40
分類程式碼代碼:
12352200

品質等級

化驗

≥98% (HPLC)

形狀

oil

顏色

colorless to yellow

儲存溫度

2-8°C

SMILES 字串

O=P(C(C)C)(C(C)C)CCCCCCCCC

生化/生理作用

Cryosim-3 is a water soluble, selective and potent agonist of TRPM8 (transient receptor potential melastatin 8) receptor. Cryosim-3 increases tear secretion in an animal model of dry eye disease. Also it relieves ocular discomfort in subjects diagnosed with DED without eye irritation.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Ying Yin et al.
Science (New York, N.Y.), 378(6616), eadd1268-eadd1268 (2022-10-14)
The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular transducer responsible for the cool sensation elicited by menthol and cold in mammals. TRPM8 activation is controlled by cooling compounds together with the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2).

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