跳轉至內容
Merck
全部照片(1)

Key Documents

SML0103

Sigma-Aldrich

AMTB 水合物

≥98% (HPLC)

同義詞:

N-(3-氨基丙基)-2-[(3-甲基苯基)甲氧基]-N-(2-噻吩基甲基)-苯甲酰胺盐酸盐(1:1) 单盐酸半乙醇半水合物

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C23H26N2O2S·HCl · xH2O
CAS號碼:
分子量::
430.99 (anhydrous basis)
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to tan

溶解度

DMSO: ≥10 mg/mL

儲存溫度

2-8°C

SMILES 字串

O=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O

InChI

1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2

InChI 密鑰

RTYVTAQFASBIDN-UHFFFAOYSA-N

應用

AMTB水合物已被用作瞬时受体电位通道、melastatin亚家族、乳腺癌细胞成员8(TRPM8) 和鼠T 细胞的抑制剂。

生化/生理作用

AMTB 是一种 2-苄氧基苯甲酸酰胺衍生物, 它可抑制电压门控钠通道(Nav)及其同工型。
AMTB是一种TRPM8选择性拮抗剂,与TRPV1或4没有交叉反应性。 icilin激活TRPM8的pIC50为6.23静脉注射给药AMTB,可以减少容量负荷膀胱的节律性收缩频率,并抑制血压和对膀胱扩张的内脏运动反射反应。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Átila Pereira-Gonçalves et al.
Pflugers Archiv : European journal of physiology, 470(12), 1803-1813 (2018-09-13)
1,8-Cineole is a cyclic monoterpenoid used in folk medicine for treatment of numerous respiratory diseases and other infections. 1,8-Cineole has anti-inflammatory, antioxidant, and myorelaxant effects, as well as low toxicity. In the present study, the effects of 1,8-cineole on contractility
Yutong Sui et al.
Fitoterapia, 145, 104631-104631 (2020-05-23)
Transient receptor potential melastatin 8 (TRPM8) is a calcium ion-permeable cation channel that is used as a prognostic marker and therapeutic target for different tumor types. To identify natural selective TRPM8 antagonists, we tested 158 traditional Chinese medicine (TCM) compounds
Tusar K Acharya et al.
Cell biology international, 45(1), 198-210 (2020-10-23)
The transient receptor potential melastatin 8 (TRPM8) is an ion channel that has been widely studied as a cold-sensitive nociceptor. However, its importance in nonneuronal cells is mostly unexplored. Here, we describe the presence and functional significance of endogenous TRPM8

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務