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Merck
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重要文件

SML3035

Sigma-Aldrich

Ziprasidone hydrochloride hydrate

≥97% (HPLC)

同義詞:

5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride hydrate, CP-88,059, CP-88,059-01, CP-88059

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About This Item

經驗公式(希爾表示法):
C21H21ClN4OS · xHCl · yH2O
CAS號碼:
分子量::
412.94 (anhydrous free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥97% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

SMILES 字串

O=C1CC(C=C(C(Cl)=C2)CCN3CCN(CC3)C4=NSC5=C4C=CC=C5)=C2N1.[xHCl].[yH2O]

InChI

1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)

InChI 密鑰

MVWVFYHBGMAFLY-UHFFFAOYSA-N

生化/生理作用

Atypical antipsychotic with 5HT1A agonist, as well as D2, 5HT2A, and 5HT1D antagonist activity.
Ziprasidone is an atypical antipsychotic with 5HT1A agonist, as well as D2, 5HT2A, and 5HT1D antagonist activity.

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險聲明

危險分類

Skin Sens. 1 - STOT RE 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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T F Seeger et al.
The Journal of pharmacology and experimental therapeutics, 275(1), 101-113 (1995-10-01)
Ziprasidone (CP-88,059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects in preclinical assays predictive of antipsychotic activity. Whereas the compound is a dopamine antagonist in vitro and in vivo, its most potent action is antagonism
C Prakash et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(2), 206-218 (1997-02-01)
The metabolism and excretion of ziprasidone (5-[2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]ethyl]-6-++ +chloroindolin-2-one hydrochloride hydrate) were studied in Long Evans rats after oral administration of a single dose of a mixture of 14C- and 3H-labeled ziprasidone. The radioactive dose was quantitatively recovered over 7 days

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