SML3723

JNJ-26854165

≥98% (HPLC)

• 同義詞: 1-N-[2-(1H-Indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine, JNJ 1, JNJ 26854165, N1-[2-(1H-Indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-benzenediamine, Serdemetan
• 經驗公式（希爾表示法）: C₂₁H₂₀N₄
• CAS號碼: 881202-45-5
• 分子量：: 328.41
• MDL號碼: MFCD16620518
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: [nH]1c2c(c(c1)CCNc3ccc(cc3)Nc4ccncc4)cccc2

描述

生化／生理作用

JNJ-26854165 (serdemetan) is an inhibitor of the E3 ligase human double minute-2 (HDM2) that inhibits cell proliferation and induces apoptosis in models of acute myeloid and lymphoid leukemias, and solid tumors. Also JNJ-26854165 inhibits cholesterol transport. JNJ-26854165 appears to stimulate cholesterol regulatory genes, but simultaneously inhibits cholesterol transport.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable