推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
solid
光學活性
[α]/D +32.1°, c = 1 in DMF(lit.)
儲存條件
desiccated
protect from light
顏色
white
溶解度
H2O: >5 mg/mL
SMILES 字串
Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChI 密鑰
OYCAEWMSOPMASE-XFULWGLBSA-N
基因資訊
human ... DRD1(1812)
尋找類似的產品? 前往 產品比較指南
應用
R(+)-SCH-23390盐酸盐可用于:
- 腹腔注射实验大鼠,研究D1受体在致敏性中的作用
- 作为D1受体选择性拮抗剂,注入颅内药物
- 作为D1受体拮抗剂,研究其对鱼类学习能力的影响
生化/生理作用
R(+)-SCH-23390盐酸盐是一种选择性D1多巴胺受体拮抗剂。在体外对5-羟色胺2 (5-HT2)和5-HT1C 血清素受体亚型具有更强的结合力。给药后R(+)-SCH-23390的半衰期为25分钟。众所周知,它具有抗定型和促僵硬作用。此外,它还对肌动活动有抑制作用。
法律資訊
经先灵葆雅许可出售。
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
客戶也查看了
SCH 23390: the first selective dopamine D1-like receptor antagonist
Cns Drug Reviews, 7(4), 399-414 (2001)
European journal of pharmacology, 128(3), 213-220 (1986-09-09)
[125I]SCH 23982, [125I]8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol, binds reversibly and with high affinity (Kd = 0.7 +/- 0.05 nM) to specific binding sites (maximum binding = 108 +/- 3.5 fmol/mg) in the caudate nucleus of the rat brain. The caudate binding site displays pharmacological
Stimulation of dopamine D1 receptor improves learning capacity in cooperating cleaner fish
Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. Royal Society (Great Britain), 283(1823), 20152272-20152272 (2016)
The Journal of pharmacology and experimental therapeutics, 226(2), 462-468 (1983-08-01)
SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol) possesses pharmacologic effects similar to standard antipsychotics, including selective supression of conditioned avoidance responding in rats and squirrel monkeys, blockade of apomorphine-induced stereotypy in rats and blockade of methamphetamine-induced lethality in aggregated mice. At effective doses in
Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists
Journal of Pharmacology and Experimental Therapeutics, 298(2), 539-550 (2001)
我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務