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Key Documents

P4875

Sigma-Aldrich

D-青霉胺

98-101%

同義詞:

3,3-二甲基-D-半胱氨酸, 3-巯基-D-缬氨酸, D-(-)-2-氨基-3-巯基-3-甲基丁酸

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About This Item

線性公式:
(CH3)2C(SH)CH(NH2)CO2H
CAS號碼:
分子量::
149.21
Beilstein:
1722375
EC號碼:
MDL號碼:
分類程式碼代碼:
51202303
PubChem物質ID:
NACRES:
NA.76

品質等級

化驗

98-101%

形狀

powder

mp

210 °C (dec.) (lit.)

溶解度

H2O: 100 mg/mL

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

CC(C)(S)[C@@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1

InChI 密鑰

VVNCNSJFMMFHPL-VKHMYHEASA-N

基因資訊

mouse ... Oprk1(18387)

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一般說明

D-青霉胺来源于相应的 β-内酰胺抗生素的水解。

應用

在肝豆状核变性病中用作抗风湿药和螯合剂。用作铜螯合剂与半胱氨酸或其他硫化物介质组分形成混合二硫化物。用于灭活蛋白-1dna 结合 ,抑制兔关节软骨细胞异步培养的生长

生化/生理作用

青霉胺是青霉素类抗生素的特征性降解产物。一个铜原子与两个青霉胺分子结合。青霉胺可减少胱氨酸尿症中过量胱氨酸的排泄。这是通过青霉胺和胱氨酸之间的二硫键互换,形成易于排泄的青霉胺-半胱氨酸二硫化物。青霉胺可干扰原胶原分子之间交联的形成,并在新形成时将其裂解。青霉胺降低 IgM 类风湿因子,抑制 T 细胞活性。

其他說明

将容器密闭保存在干燥和通风良好的地方。

象形圖

Health hazard

訊號詞

Warning

危險聲明

危險分類

Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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M L Handel et al.
Molecular pharmacology, 50(3), 501-505 (1996-09-01)
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P Jaffray et al.
Annals of the rheumatic diseases, 43(2), 333-338 (1984-04-01)
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