推薦產品
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
CC(NC1=NC(C2=CC=CC(NS(C3=C(C=CC=C4N(C)C)C4=CC=C3)(=O)=O)=C2)=CS1)=O
InChI
1S/C23H22N4O3S2/c1-15(28)24-23-25-20(14-31-23)16-7-4-8-17(13-16)26-32(29,30)22-12-6-9-18-19(22)10-5-11-21(18)27(2)3/h4-14,26H,1-3H3,(H,24,25,28)
InChI 密鑰
LBSMEKVVMYSTIH-UHFFFAOYSA-N
生化／生理作用
BiP/GRP78/HSPA5 伴侣的选择性配体，增加内质网应激，导致多种癌细胞系自噬和凋亡
HA15 是 BiP/GRP78/HSPA5 伴侣的选择性配体，可增加内质网应激，导致包括黑素瘤细胞在内的多种癌细胞自噬和凋亡。HA15 抑制 BiP 的 ATPase 活性。Ha15 抑制了注射 A375 黑色素瘤细胞的小鼠的肿瘤发展。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Michaël Cerezo et al.
Autophagy, 13(1), 216-217 (2016-10-30)
Treatment of melanoma has significantly advanced over the last decade, with the development of targeted therapies against the MAPK pathway and immunotherapies to reactivate antitumor immunity. Unfortunately, currently more than 50% of patients are in treatment failure. Thus, identification of
Michaël Cerezo et al.
Cancer cell, 29(6), 805-819 (2016-05-31)
We have discovered and developed a series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. Our
Rossella Benedetti et al.
Biomedicines, 9(9) (2021-09-29)
Polyphenols have been shown to possess several beneficial properties, including properties involved in the prevention or treatment of cancer. Among these polyphenols, a leading role is played by dihydroxyphenylethanol (DPE), the most powerful antioxidant compound contained in the olive oil.
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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