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About This Item
經驗公式（希爾表示法）:
C9H6Cl2N2OS
CAS號碼:
分子量：:
261.13
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
ClC1=C(C(NN)=O)SC2=CC=CC(Cl)=C21
InChI
1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14)
InChI 密鑰
HSSHUDKWJRJKPV-UHFFFAOYSA-N
一般說明
抑制 8-氧代鸟嘌呤 DNA 糖基化酶-1（OGG1），可用于治疗某些类型的癌症的单一疗法或联合疗法。
生化／生理作用
OGG1 抑制剂 O8 是 8-氧鸟嘌呤 DNA 糖基化酶 1（OGG1）的有效抑制剂，该酶是 DNA 碱基切除修复（BER）途径的一部分，正在成为癌症治疗的药物靶标。 OGG1 抑制剂 O8 的 IC50 值为 220 nM，相对于其他几种 DNA 修复糖基化酶，其对 OGG1 的选择性为 >100 倍。 O8 在 OGG1 催化过程中通过抑制席夫碱的形成发挥作用。它不能阻止 OGG1 与包含 7,8-二氢-8-氧鸟嘌呤（8-氧代-瓜氨酸）的底物的 DNA 结合。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Nathan Donley et al.
ACS chemical biology, 10(10), 2334-2343 (2015-07-29)
The DNA base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of DNA damage induced by oxidation, alkylation, and deamination. Early results from clinical trials suggest
Mingxin Chang et al.
Frontiers in pharmacology, 11, 610205-610205 (2021-02-02)
Background: Oncogenic transformation is associated with elevated oxidative stress that promotes tumor progression but also renders cancer cells vulnerable to further oxidative insult. Agents that stimulate ROS generation or suppress antioxidant systems can drive oxidative pressure to toxic levels selectively
Xu Zheng et al.
Journal of innate immunity, 1-22 (2022-05-06)
The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s). However, the mechanisms for these processes are not fully understood.
Hongge Wang et al.
Oncogene, 39(14), 2905-2920 (2020-02-08)
PARP1 and PARP2 play critical roles in regulating DNA repair and PARP inhibitors have been approved for the treatment of BRCA1/2-mutated ovarian and breast cancers. It has long been known that PARP inhibition sensitizes cancer cells to DNA-damaging cytotoxic agents
Wenjing Hao et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7427-7441 (2020-05-08)
8-Oxoguanine DNA glycosylase1 (OGG1)-initiated base excision repair (BER) is the primary pathway to remove the pre-mutagenic 8-oxo-7,8-dihydroguanine (8-oxoG) from DNA. Recent studies documented 8-oxoG serves as an epigenetic-like mark and OGG1 modulates gene expression in oxidatively stressed cells. For this
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