推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D -20 to -27°, c = 0.4 in methanol
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
N4(CCCNC4=O)[C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@@H](NC(=O)COc3c(cccc3C)C)Cc2ccccc2)Cc1ccccc1
InChI
1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
InChI 密鑰
KJHKTHWMRKYKJE-SUGCFTRWSA-N
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應用
洛匹那韦已被用作ZMPSTE24和人类免疫缺陷病毒蛋白酶的抑制剂。
生化／生理作用
洛匹那韦是一种抗病毒HIV蛋白酶抑制剂。 单独洛匹那韦具有不足的生物利用度，因此它通常与HIV蛋白酶抑制剂利托那韦联合用于治疗，利托那韦可抑制细胞色素P450-3A4（CYP3A4），其是一种能够代谢蛋白酶抑制剂的肝酶。洛匹那韦还具有抑制ZMPSTE24（锌金属肽酶STE24）的能力。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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