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About This Item
經驗公式（希爾表示法）:
C21H21BrN4O5
CAS號碼:
分子量：:
489.32
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
BrC1=C(OC2=C(C(NC)=O)C=CC=C2)N=C(NC3=CC(OC)=C(OC)C(OC)=C3)N=C1
InChI
1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
InChI 密鑰
NEXGBSJERNQRSV-UHFFFAOYSA-N
應用
SBI-0206965已用于研究其对镉转化的前列腺上皮细胞生长的影响。
生化／生理作用
SBI-0206965 是丝氨酸/苏氨酸自噬起始激酶 ULK1 和 ULK2 的强效选择性抑制剂，对 ULK1 具有选择性。 SBI-0206965对于ULK1的IC50值为108 nM，而对于ULK2为711 nM。 肿瘤细胞需要自噬来清除错误折叠的蛋白质或受损的细胞器。SBI-0206965可抑制mTOR抑制诱导的细胞自噬。 mTOR信号通常在许多肿瘤中过度活跃，并能驱动增殖，所以mTOR抑制剂作为抗癌药物正在被研究。 然而，mTOR抑制也会导致激活依赖于ulk1的自噬生存反应，而mTOR抑制剂的大多数结果最多只能起到细胞抑制作用。 SBI-0206965协同mTOR抑制诱导细胞凋亡和死亡。
由于大多数肿瘤细胞通过自噬机制存活，因此抑制自噬诱导物Unc-51（丝氨酸/苏氨酸蛋白激酶）样自噬激活激酶（ULK1和ULK2）可能在癌症治疗中有用。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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