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Merck
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重要文件

171261

Sigma-Aldrich

Dorsomorphin

≥95% (HPLC), liquid, AMPK inhibitor, Calbiochem

同義詞:

InSolution AMPK抑制剂，化合物C

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About This Item

經驗公式（希爾表示法）:
C24H25N5O
CAS號碼:
866405-64-3
分子量：:
399.49
MDL號碼:
MFCD08705402
分類程式碼代碼:
12352200
NACRES:
NA.77

產品名稱

AMPK抑制剂，化合物C, InSolution, ≥95%, 10 mM, AMPK Inhibitor

品質等級

100

化驗

≥95% (HPLC)

形狀

liquid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)
protect from light

運輸包裝

wet ice

儲存溫度

2-8°C

SMILES 字串

[n]21ncc(c2ncc(c1)c4ccc(cc4)OCCN5CCCCC5)c3ccncc3

InChI

1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChI 密鑰

XHBVYDAKJHETMP-UHFFFAOYSA-N

一般說明

一种细胞可透过性吡唑并嘧啶化合物，可抑制KDR/VEGFR2、ALK2/BMPR-1、AMPK激酶活性（IC50 = 25.1、148和234.6 nM），而对对ALK5/TGFβR-I、ZAPK、Syk、PKCθ、PKA或JAK3的作用却大大降低或几乎没有。研究表明，可阻断斑马鱼活体胚胎中BMP途径依赖性背腹发育（EC100 = 2.5 µ）和VEGF信号转导依赖性肌间血管形成（EC50 = 5 µM）。通常与 AMPK 激活剂 AICAR（货号 123040）和/或二甲双胍（货号 317240）结合使用，以研究 AMPK 依赖性细胞事件在体外和动物体内的生理反应。

生化／生理作用

主要靶标
AMPK
产物与ATP竞争。
可逆性：是
细胞可渗透性：具有
阻断斑马鱼活体胚胎中BMP途径依赖性背腹发育的EC100 = 2.5 µM；阻断VEGF信号转导依赖性肌间血管形成的EC50 = 5 µM
靶标IC50：抑制KDR/VEGFR2、ALK2/BMPR-1、AMPK激酶活性分别为25.1、148和234.6 nM

包裝

用惰性气体包装

警告

毒性：刺激性（B）

外觀

提供 10 mM（1 mg/250 µl）的 AMPK 抑制剂，化合物 C（货号171260），溶剂为DMSO

重構

初次使用后，等分并冷冻（-20°C）。一旦打开，储备溶液在 -20°C 下可稳定保存 3 个月。

其他說明

Hao, J., et al. 2010.ACS Chem.Biol.5, 245.
Kim, E.K., et al. 2004.J. Biol. Chem.279, 19970.
Lee, M., et al. 2003.J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003.Cell115, 577.
Fryer, L.G., 2002.FEBS Lett.531, 189.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

188.6 °F - closed cup - (Dimethylsulfoxide)

閃點（°C）

87 °C - closed cup - (Dimethylsulfoxide)

分析證明 (COA)

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