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Key Documents

SML0693

Sigma-Aldrich

LY-333531 盐酸盐

≥98% (HPLC)

同義詞:

(9S)-9-[(二甲氨基)甲基] -6,7,10,11-四氢-9H,18H-5,21:12,17-二甲基二苯并[e,k]吡咯并[3,4-h] [ 1,4,13]草二氮杂环十六烷-18,20(19H)-二酮 盐酸盐, 芦丁黄素

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About This Item

經驗公式(希爾表示法):
C28H28N4O3 · HCl
CAS號碼:
分子量::
505.01
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated
protect from light

顏色

orange-red

溶解度

DMSO: 10 mg/mL, clear

儲存溫度

−20°C

InChI

1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1

InChI 密鑰

NYQIEYDJYFVLPO-FERBBOLQSA-N

一般說明

LY-333531盐酸盐也被称为ruboxistaurin。

應用

LY-333531盐酸盐/ruboxistaurin已被用作PKCB阻断剂,以比较来源于受刺激的野生型细胞的磷酸肽与来源于PKCB敲除细胞或野生型细胞的磷酸肽。

生化/生理作用

LY333531是蛋白激酶Cβ(PKCβ; PKCβ1和PKCβ2的IC50值分别为4.7和5.9 nM)的一种有效抑制剂。PKCβ亚型在氧化应激状态下过表达,尤其是与糖尿病有关。在糖尿病大鼠中,LY333531可改善视网膜的血流量和白细胞截留,并防止心肌肥大和心脏功能障碍。

特點和優勢

该化合物是受体分类及信号转导手册上PKC页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

其他說明

光敏感

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Clinical and experimental pharmacology & physiology, 44(7), 760-770 (2017-04-11)
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