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重要文件

S7446

Sigma-Aldrich

超氧化物歧化酶 来源于牛红细胞

BioUltra, lyophilized powder, ≥4,500 units/mg protein, ≥97% (SDS-PAGE)

同義詞:

SOD, 超氧化物:超氧化物氧化还原酶

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About This Item

CAS號碼:
酶委員會編號:
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
NACRES:
NA.54

產品線

BioUltra

品質等級

化驗

≥97% (SDS-PAGE)

形狀

lyophilized powder

比活性

≥4,500 units/mg protein

分子量

32.5 kDa

成份

Protein, ≥95% biuret

相關疾病

arthritis

儲存溫度

−20°C

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一般說明

Research area: Cell signaling. Superoxide Dismutase (SOD) is found in allaerobic cells of the animals, plants, and microorganisms. It is a low molecularweight protein that exists as three different forms such as manganese SOD,copper–zinc SOD, and extracellular SOD.

應用

来自牛红细胞的超氧化物歧化酶已用于评估佐剂诱导的关节炎的活性参数的研究中。 来自牛红细胞的超氧化物歧化酶也已用于一项研究中,以简化在10-羧基癸基琼脂糖凝胶上使用电荷控制的疏水色谱法纯化超氧化物歧化酶的过程。

生化/生理作用

牛红细胞来源的超氧化物歧化酶可催化超氧化物自由基歧化为过氧化氢和分子氧。作为一种抗氧化剂,它在保护细胞免受氧自由基毒性作用方面起着至关重要的作用。与一氧化氮(NO)竞争超氧化物阴离子(可与NO反应生成过亚硝酸盐),因此SOD能促进NO的活性。在培养的大鼠卵泡、神经细胞系和转基因小鼠中,SOD也表现出抑制细胞凋亡的作用。

單位定義

在pH 7.8,25℃条件下,3.0mL反应体积中,一个单位可在黄嘌呤氧化酶的偶联系统中抑制细胞色素c的减少达到50%。黄嘌呤氧化酶浓度应每分钟产生 0.025±0.005 的初始 ΔA550

象形圖

Health hazard

訊號詞

Danger

危險聲明

防範說明

危險分類

Resp. Sens. 1

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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A García-González et al.
Archives of medical research, 30(2), 132-137 (1999-06-18)
The purpose of this work was to evaluate the effect of superoxide dismutase (SOD) on primary swelling, lipoperoxidation, body thymus, and spleen weight in the adjuvant-induced arthritis (AIA) model in rats. Orally and intraperitoneally administered SOD (100 U/kg) from bovine
Purification of pro- and eukaryotic superoxide dismutases by charge-controlled hydrophobic chromatography
Grunow, M. and W. Schopp
Journal of Chromatography A, 590, 247-253 (1992)
M S Silva et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1104, 262-268 (2018-12-24)
Zinc (Zn) is an element essential to all living organisms and it has an important role as a cofactor of several enzymes. In fish, Zn deficiency has been associated with impaired growth, cataracts, skeletal abnormalities and reduced activity of various
Johannes Björnerås et al.
The FEBS journal, 281(3), 814-824 (2014-03-13)
The molecular determinants for selectivity of ligand binding to membrane receptors are of key importance for the understanding of cellular signalling, as well as for rational therapeutic intervention. In the present study, we target the interaction between the κ opioid
Ashley E Frakes et al.
Neuron, 81(5), 1009-1023 (2014-03-13)
Neuroinflammation is one of the most striking hallmarks of amyotrophic lateral sclerosis (ALS). Nuclear factor-kappa B (NF-κB), a master regulator of inflammation, is upregulated in spinal cords of ALS patients and SOD1-G93A mice. In this study, we show that selective

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