R8626

利福霉素 SV 钠盐

potency: ≥ 900 IU/mg (anhydrous basis)

• 同義詞: 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl- 21-acetate monosodium salt, Rifamycin SV monosodium salt
• 經驗公式（希爾表示法）: C₃₇H₄₆NNaO₁₂
• CAS號碼: 14897-39-3
• 分子量：: 719.75
• EC號碼: 238-965-7
• 分類程式碼代碼: 51283601
• PubChem物質ID: 329824038
• NACRES: NA.76

屬性

• 形狀: powder
• 品質等級: 200
• 效力: ≥ 900 IU/mg (anhydrous basis)
• 溶解度: ethanol: soluble 50 mg/mL
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 作用方式: protein synthesis | interferes
• SMILES 字串: [Na+].CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)cc([O-])c4c3C2=O
• InChI: 1S/C37H47NO12.Na/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);/q;+1/p-1/b11-10+,14-13+,17-12-;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;/m0./s1
• InChI 密鑰: YVOFSHPIJOYKSH-NLYBMVFSSA-M

描述

一般說明

Chemical structure: macrolide

應用

Rifamycin SV is a broad-spectrum semisynthetic antimicrobial agent of the rifamycin group. It is used to study potential genes, such as rif15 and rif16, which may be involved in the conversion of rifamycin SV into rifamycin B.

生化／生理作用

Rifamycin SV inhibits selective (E. coli, B. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunit, a mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.

包裝

1g,5g

其他說明

Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Air sensitive. Store under inert gas

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)