推薦產品
產品名稱
RepSox, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
solid
溶解度
DMSO: >20 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cc1cccc(n1)-c2n[nH]cc2-c3ccc4ncccc4n3
InChI
1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChI 密鑰
LBPKYPYHDKKRFS-UHFFFAOYSA-N
應用
RepSox已被用于转化生长因子β激酶1型受体(ALK5)的抑制剂。此外，还可用于基本培养基成分，以培养人类多能干细胞。
生化／生理作用
RepSox 抑制 TGF-β 受体信号。
RepSox 抑制 TGF-β 受体信号。逆转录病毒转导 Sox2、Oct4 和 Klf4 基因导致体细胞直接重编程为诱导多能干细胞 (iPSC)。
RepSox通过抑制SMAD族成员3 (Smad3)和c-Jun n -端激酶(JNK)途径/激活蛋白质1 (AP-1)途径，抑制破骨细胞分化、骨组织吸收和卵巢切除术(OVX)诱导的骨质疏松症(OP)。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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