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Merck
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Key Documents

PZ0233

Sigma-Aldrich

PF-06424439

≥98% (HPLC)

同義詞:

[(3R)-1-[2-[1-(4-氯-1H-吡唑-1-基)环丙基]-3H-咪唑并 [4,5-b] 吡啶-5-基]-3-哌啶基]-1-吡咯烷甲酮甲磺酸盐

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About This Item

經驗公式(希爾表示法):
C22H26ClN7O · CH3SO3H
CAS號碼:
分子量::
536.05
分類程式碼代碼:
12352200
PubChem物質ID:

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D +7 to +11°, c = 1.0 in methanol

顏色

white to light brown

溶解度

H2O: 10 mg/mL, clear

儲存溫度

room temp

SMILES 字串

O=C([C@@H]1CCCN(C2=NC(NC(C3(CC3)N4N=CC(Cl)=C4)=N5)=C5C=C2)C1)N6CCCC6.CS(=O)(O)=O

InChI

1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27);1H3,(H,2,3,4)/t15-;/m1./s1

InChI 密鑰

ZSTFDNQQOJUJFL-XFULWGLBSA-N

應用

使用 PF-06424439 作为二酰基甘油酰基转移酶 2(DGAT2)的抑制剂:
  • 研究其对结肠上皮细胞和结肠癌干细胞中细胞死亡率和脂质合成的影响
  • 研究其对 HeLa 细胞的影响
  • 研究其对 HT-1080 细胞中性脂类合成的抑制作用

生化/生理作用

PF-06424439 具有降低血脂异常大鼠肝脂质水平的作用。
PF-06424439 是一种强效选择性甘油二酯酰基转移酶 2 (DGAT2) 抑制剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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