P8982

Anti-phospho-p53 (pSer³⁹²) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• MDL號碼: MFCD02097164
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous glycerol solution
• 分子量: antigen 53 kDa
• 物種活性: mouse, human
• 技術: microarray: suitable; western blot (chemiluminescent): 1:1,000 using p53 fusion proteins with CKII phosphorylation or an extract of hydroxyurea-treated MvILu cells
• UniProt登錄號: P04637
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... TP53(7157) ; mouse ... Trp53(22059)

描述

一般說明

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

特異性

Does not react with non-phosphorylated p53.

免疫原

synthetic peptide corresponding to residues around Ser³⁹² of human p53 conjugated to KLH.

生化／生理作用

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

外觀

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

準備報告

Purified using protein A and peptide affinity chromatography.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable