P5248

依替膦酸钠 二钠 水合物

≥97% (NMR), solid

• 同義詞: Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
• 經驗公式（希爾表示法）: C₂H₆Na₂O₇P₂ · xH₂O
• CAS號碼: 7414-83-7
• 分子量：: 249.99 (anhydrous basis)
• EC號碼: 231-025-7
• MDL號碼: MFCD00152567
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329820220
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥97% (NMR)
• 形狀: solid
• 顏色: white
• mp: >300 °C
• 溶解度: H₂O: ≥10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
• InChI: 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• InChI 密鑰: GWBBVOVXJZATQQ-UHFFFAOYSA-L

描述

應用

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

生化／生理作用

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC₅₀ = 80 μM) as compared to the nitrogen containing bisphosphonates

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves