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重要文件

A4978

Sigma-Aldrich

阿屈膦酸盐 钠 三水合物

≥97% (NMR), powder

同義詞:

4-氨基-1-羟基-1-膦酸丁酯,单钠, MK-217

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About This Item

經驗公式(希爾表示法):
C4H12NaNO7P2 · 3 H2O
CAS號碼:
分子量::
325.12
MDL號碼:
分類程式碼代碼:
41106300
PubChem物質ID:
NACRES:
NA.77

化驗

≥97% (NMR)

形狀

powder

顏色

white

溶解度

water, double-distilled: 10 mg/mL

儲存溫度

−20°C

SMILES 字串

[Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O

InChI

1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1

InChI 密鑰

DCSBSVSZJRSITC-UHFFFAOYSA-M

基因資訊

human ... FDPS(2224)

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應用

阿仑膦酸钠三水合物已被用于:
  • 钛植入物的磷酸钙纳米颗粒(nCaP)二膦酸盐(BP)涂层并用于分析其成骨能力
  • 从老年骨质疏松症患者和健康人群中分离的人骨髓基质细胞(hBMSC)的成骨分化
  • 处理成骨细胞祖细胞和成骨细胞并通过传统测定和简单的数字图象分析研究其对成骨细胞行为的影响
  • 生化/生理作用

    阿仑膦酸钠三水合物是一种骨吸收抑制剂;法尼基二磷酸合成酶抑制剂 (IC 50 = 460 nM);CD45 蛋白酪氨酸磷酸酶抑制剂。
    阿伦膦酸盐是一种含氮二膦酸盐,可阻断甲羟戊酸途径 并限制破骨功能和活性。阿仑膦酸钠三水合物是一种骨吸收抑制剂、法尼基二磷酸合成酶抑制剂和 CD45 蛋白酪氨酸磷酸酶抑制剂。

    儲存和穩定性

    重溶后,建议在-20°C下分装冻存。储备液在-20°C条件下可稳定保存6个月。

    象形圖

    Exclamation mark

    訊號詞

    Warning

    危險聲明

    危險分類

    Acute Tox. 4 Oral

    儲存類別代碼

    11 - Combustible Solids

    水污染物質分類(WGK)

    WGK 3

    閃點(°F)

    Not applicable

    閃點(°C)

    Not applicable

    個人防護裝備

    dust mask type N95 (US), Eyeshields, Gloves


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