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一般說明
研究领域：细胞信号传导磷酸二酯酶i （PDEI）存在于三种亚型PDE1A、PDE1B和PDE1C(2)中，它们位于心血管、中枢神经系统和其他器官中。
應用
本文用西方响尾蛇（Crotalus atrox）的磷酸二酯酶I分析了磷酸二酯酶I对中性粒细胞内钙浓度的影响。其也可与其他酶联合用于测定磷酸酶的活性。
磷酸二酯酶I是西部菱形响尾蛇的产物P4506，用于钙调素的磷酸二酯酶活化试验。 它被加入水解AMP。
生化／生理作用
磷酸二酯酶I可破坏磷酸二酯键并催化各种核苷酸多磷酸盐的水解。 磷酸二酯酶I是由磷脂酰肌醇特异性磷脂酶C从真核生物细胞膜释放出来的。磷酸二酯酶I可以水解3′,5′-环腺苷单磷酸（cAMP）和3′,5′-环鸟苷单磷酸（cGMP）。它与Ca2+/钙调蛋白（CaM）形成复合物，导致其催化活性的激活。PDEI显示出治疗癌症、疾病、神经认知、肺、代谢、心脏、肾脏、神经系统疾病和内分泌异常的生物治疗效果。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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