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About This Item
經驗公式（希爾表示法）:
C12H9N3O5S
CAS號碼:
分子量：:
307.28
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
化驗
≥98% (HPLC)
形狀
powder
起源
Romark
儲存溫度
2-8°C
SMILES 字串
CC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+]([O-])=O
InChI
1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
InChI 密鑰
YQNQNVDNTFHQSW-UHFFFAOYSA-N
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一般說明
硝唑尼特（NTZ）是一种噻唑化物类（thiazolide）化合物，它是一种结构与氯硝柳胺相似的抗寄生虫药。
應用
硝唑尼特已被用于：
- 测试其对基孔肯雅病毒的抗病毒活性
- 作为抗原生动物剂用于测试其对多种癌细胞系细胞活力的影响
- 测试其对感染人巨细胞病毒（HCMV）的人成纤维细胞HFF细胞的影响
生化／生理作用
硝唑尼特是丙酮酸-铁氧还蛋白氧化还原酶(PFOR)抑制剂，FDA批准的抗寄生虫药(2002)。近期研究(C & EN Sept. 14, 2009, p. 28)表明，硝唑尼特可杀死非复制和复制的结核菌，未检测到明显的耐药性。
硝唑尼特（NTZ）通过作用于激酶信号传导通路来促进自噬，并作用于分枝杆菌中雷帕霉素复合物1（mTORC1）的哺乳动物靶点。在体外研究中，它具有抗病毒特性，并有效地阻止了基孔肯雅病毒的进入和释放。NTZ还可以抑制早期阶段的日本脑炎病毒（JEV）感染，并具有治疗其他病毒感染的潜力，包括登革热、乙型肝炎（HBV）、冠状病毒和人类免疫缺陷病毒（HIV）。它具有抗恶性肿瘤功能，并可通过促进原癌基因c-Myc抑制来诱导细胞凋亡，从而导致肿瘤抑制。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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