M0440

丝裂霉素 C 来源于头状链霉菌

meets USP testing specifications

• 同義詞: Mitomycin
• 經驗公式（希爾表示法）: C₁₅H₁₈N₄O₅
• CAS號碼: 50-07-7
• 分子量：: 334.33
• Beilstein: 7231816
• EC號碼: 200-008-6
• MDL號碼: MFCD00078109
• 分類程式碼代碼: 12352203
• PubChem物質ID: 24896554
• NACRES: NA.76

屬性

• 生物源: Streptomyces caespitosus
• 品質等級: 200
• 顏色: blue-violet
• 溶解度: H₂O: 40 mg/mL, clear to very slightly hazy, colorless; H₂O: soluble
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: DNA synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: [H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O
• InChI: 1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
• InChI 密鑰: NWIBSHFKIJFRCO-WUDYKRTCSA-N

描述

一般說明

Chemical structure: aziridine

應用

Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.

生化／生理作用

作用机制：该产物是专门针对鸟嘌呤核苷序列5′-CpG-3′的烷基化剂。它通过与DNA共价反应，在DNA互补链之间形成交联来抑制DNA合成。 这种相互作用可防止DNA互补链分离，从而抑制DNA复制。

抗菌谱：丝裂霉素C具有很强的抗肿瘤活性，尤其是对艾氏腹水瘤细胞，对革兰氏阳性和革兰氏阴性细菌具有很强的杀菌作用。

注意

Stock solutions should be filter sterilized and stored at 2-8 °C in the dark. Solutions at pH 6-9 can be stored at 0-5 °C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.

準備報告

Mitomycin C is soluble in water at .5 mg/mL, with a pH of 6.0-7.5. It undergoes rapid degradation in acidic solutions with pH<6, and is mostly likely to retain activity in solutions with a pH between 6-9.

安全資訊

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300,H351
• 防範說明: P201 - P301 + P310 + P330
• 危險分類: Acute Tox. 2 Oral - Carc. 2
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges