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重要文件

N8141

Sigma-Aldrich

4-硝基喹啉 N -氧化物

≥98%

同義詞:

1-氧化-4-硝基喹啉, 4-NQO

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About This Item

經驗公式(希爾表示法):
C9H6N2O3
CAS號碼:
分子量::
190.16
Beilstein:
165756
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

≥98%

顏色

yellow to brown

mp

154-156 °C (lit.)

溶解度

acetone: soluble, clear to hazy

儲存溫度

−20°C

SMILES 字串

[O-][N+](=O)c1cc[n+]([O-])c2ccccc12

InChI

1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H

InChI 密鑰

YHQDZJICGQWFHK-UHFFFAOYSA-N

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一般說明

4-硝基喹啉N-氧化物是一种广泛应用于化学研究和开发的喹啉衍生物。

應用

4-硝基喹啉 N-氧化物已被用作模型化合物以研究其致癌作用。

生化/生理作用

在试验条件下可诱发皮肤和肺肿瘤。

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges


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分析證明 (COA)

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存取文件庫

The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO-and t-BOOH-induced mutagenesis in coli.
Nikolic B, et al.
Archives of Biological Sciences, 63(1), 117-128 (2011)
Interplay of DNA repair, homologous recombination, and DNA polymerases in resistance to the DNA damaging agent 4-nitroquinoline-1-oxide in Escherichia coli.
Williams AB, et al.
DNA Repair, 9(10), 1090-1097 (2010)
Ye Du et al.
Environment international, 135, 105369-105369 (2019-12-17)
Effluents from wastewater treatment plants (WWTPs) may contain various pollutants with potential toxic effects. Ozonation is widely applied to purify wastewater, which may influence the toxicity and water quality indices simultaneously. The main goal of this study was to reveal
Jing Li et al.
Oral oncology, 49(4), 299-305 (2012-11-29)
Lymph node metastasis is one of the most important prognostic factors in oral squamous cell carcinoma. However, regional lymph node metastasis from oral cancer has barely been investigated in 4-nitroquinoline-1-oxide (4NQO) models. In this study, we developed a 4NQO-treated mouse
Ting-Hui Chu et al.
Cancer letters, 337(1), 115-124 (2013-06-04)
miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211

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US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

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