推薦產品
生物源
human
品質等級
重組細胞
expressed in NSO cells
化驗
≥95% (SDS-PAGE)
形狀
lyophilized powder
分子量
α-chain ~120 & 150 kDa
β subunit ~46 & 50 kDa
包裝
pkg of 50 μg
雜質
endotoxin, tested
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... IGF1R(3480)
相關類別
一般說明
IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.
應用
Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.
生化／生理作用
Binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
外觀
Lyophilized from a 0.2 μm solution in phosphate buffered saline.
分析報告
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.
The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Sandra Heskamp et al.
PloS one, 10(2), e0117745-e0117745 (2015-02-14)
The insulin-like growth factor 1 receptor (IGF-1R) may be involved in the development of resistance against conventional cancer treatment. The aim of this study was to assess whether IGF-1R expression of breast tumors changes during neoadjuvant therapy and to study
Xin Huang et al.
PloS one, 10(7), e0133152-e0133152 (2015-07-15)
Patients with metastatic or recurrent and refractory sarcomas have a dismal prognosis. Therefore, new targeted therapies are urgently needed. This study was designed to evaluate chimeric antigen receptor (CAR) T cells targeting the type I insulin-like growth factor receptor (IGF1R)
Jin-Ho Choi et al.
The Journal of clinical endocrinology and metabolism, 96(1), E130-E134 (2010-10-22)
Mutations in the IGF1R gene result in intrauterine growth retardation and postnatal growth failure. The objective of this study was to describe the clinical features of subjects with a mutation in the IGF1R gene and to evaluate the molecular and
Robert Root-Bernstein et al.
Frontiers in endocrinology, 5, 118-118 (2014-08-08)
Insulin (INS) resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome, and obesity. The mechanism by which INS and estrogen interact is unknown. We hypothesize that estrogen binds directly to
文章
Huntington's disease (HD) is an autosomal dominant, late-onset neurodegenerative disorder characterized by a selective neuronal cell death in the cortex and striatum leading to cognitive dysfunction, motor impairment and behavioral changes.
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