SML3169

NR162

≥98% (HPLC)

• 同義詞: 4-(Cyclopentylamino)-2-(2,5-dibromo-4-methylbenzylamino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide
• 經驗公式（希爾表示法）: C₂₄H₃₀Br₂N₆O₃
• 分子量：: 610.34
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C

描述

生化／生理作用

NR162 is a potent and selective (per DiscoverX KINOMEScan) inhibitor against the calcium/calmodulin-dependent serine protein kinase CASK (Kd = 22 nM by ITC; IC50 = 80 nM by NanoBRET) with much reduced or little potency against other kinases tested (IC50 = 3.8 μM/TYRO3, 18.2 μM/ERBB3, >20 μM/ABL1, AURKC, RPS6KA6, PIKFYVE, RPS6KA5, LRRK2, STK38L by NanoBRET).

Potent and selective inhibitor against the calcium/calmodulin-dependent serine protein kinase CASK.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable