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I3766

Sigma-Aldrich

异甘草素

powder

同義詞:

(E)-1-(2,4-二羟基苯基)-3-(4-羟基苯基)-2-丙烯-1-酮, 4,2',4'-三羟基查尔酮

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About This Item

經驗公式(希爾表示法):
C15H12O4
CAS號碼:
分子量::
256.25
Beilstein:
1914296
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77

形狀

powder

品質等級

顏色

yellow to orange

溶解度

H2O: <0.1 mg/mL
methanol: 10 mg/mL
DMSO: 20 mg/mL

儲存溫度

2-8°C

SMILES 字串

Oc1ccc(cc1)\C=C\C(=O)c2ccc(O)cc2O

InChI

1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+

InChI 密鑰

DXDRHHKMWQZJHT-FPYGCLRLSA-N

基因資訊

尋找類似的產品? 前往 產品比較指南

一般說明

异甘草素是一种芳香族酮,属于查耳酮化合物类。它来源于甘草,是药品和食品中的一种成分。

應用

异甘草素已被用于:
  • 作为斑马鱼胚胎中的骨形态发生蛋白(BMP)激动剂
  • 作为斑马鱼胚胎中的鸟苷酸环化酶激活剂
  • 用于测试其对Epstein-Barr病毒相关胃癌的抗肿瘤和抗病毒作用

生化/生理作用

异甘草素是一种可溶性鸟苷酸环化酶激活剂,具有抗肿瘤活性。它还具有抗氧化、抗血小板和雌激素特性。

特點和優勢

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

注意

光敏性、吸湿性

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

S Yamamoto et al.
Carcinogenesis, 12(2), 317-323 (1991-02-01)
A topical application of a chalcone derivative, 4,2',4'-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. In addition, isoliquiritigenin potently inhibited 7,12-dimethylbenz[alpha]anthracene (DMBA)-initiated and
Kai-Lee Wang et al.
Expert opinion on therapeutic targets, 17(4), 337-349 (2013-01-19)
Isoliquiritigenin (ISL) is a natural phenolic compound extracted from licorice. Previous studies have shown that ISL is a potent antioxidant with anti-inflammatory and antitumor activities. The anti-invasive activity of ISL was still unclear. The actual causes of death for most
M Tawata et al.
European journal of pharmacology, 212(1), 87-92 (1992-02-25)
The mechanism was studied by which isoliquiritigenin, a new aldose reductase inhibitor purified from licorice (Glycyrrhizae radix), inhibits platelet aggregation. This new agent significantly inhibited the phosphorylation of 40,000- and 20,000-dalton proteins, and inhibited the formation of 12 (S)-hydroxy-5,8,10-heptadecatrienoic acid
Xuan Yuan et al.
Journal of Asian natural products research, 14(8), 789-798 (2012-06-15)
This study focuses on the relationship between the apoptosis induced by isoliquiritigenin (ISL) and the production of reactive oxygen species (ROS). Cell viability was evaluated using sulforhodamine B assay. The apoptotic rate was determined via flow cytometry. Intracellular ROS level
Xuan Yuan et al.
Recent patents on anti-cancer drug discovery, 8(2), 191-199 (2012-09-12)
Isoliquiritigenin (ISL), a licorice chalconoid, is a bioactive agent with chemopreventive potential that has been patented for tumor treatment in China. This study investigated the mechanisms of ISL-induced apoptosis in ovarian carcinoma SKOV-3 cells. Cell viability was evaluated using a

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