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一般說明
普拉染料根皮素属于二氢查耳酮类。
苹果中发现的主要多酚;根皮苷苷元。
應用
使用根皮素:
- 研究其对2-[N-(7-硝基苯-2-乙二酸-1,3-二嗪农-4-基)氨基]-2-脱氧-d-葡萄糖(2-NBDG) 和 2-[N-(7-硝基苯-2-乙二酸-1,3-二嗪农-4-基)氨基]-2-脱氧-l-葡萄糖 (2-NBDLG)摄取的影响
- 培养细胞微泡,以在放射配基摄取分析中抑制GLUT1(葡萄糖转运蛋白1)介导的转运
- 作为KRH缓冲液的组成部分,体外抑制滋养层细胞对葡萄糖的摄取
生化/生理作用
与连-二羰基化合物如乙二醛和甲基乙二醛反应,防止与生物大分子的细胞毒性结合。
根皮素能降低脂质双层的界面偶极能。根皮素通过抑制蛋白激酶C (PKC)活性和刺激程序性细胞死亡而具有抗肿瘤作用。研究发现其能抑制GLUT(葡萄糖转运蛋白)和水通道蛋白的转运功能。
阻断L型Ca2+通道;激活两栖动物有髓神经纤维中的Ca2+-激活K+通道。单羧酸转运蛋白抑制剂。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
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文章
We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.
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