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I1286

Sigma-Aldrich

淫羊藿甙

≥94% (HPLC)

同義詞:

4′-O-甲基-8-γ，γ-dimethylallylkaempferol-3-鼠李糖苷素-7-葡糖苷

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About This Item

經驗公式（希爾表示法）:
C33H40O15
CAS號碼:
489-32-7
分子量：:
676.66
MDL號碼:
MFCD00210516
分類程式碼代碼:
12352205
PubChem物質ID:
329815347
NACRES:
NA.25

品質等級

100

化驗

≥94% (HPLC)

顏色

light yellow to yellow

溶解度

DMSO: 50 mg/mL, clear, colorless to dark yellow

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

room temp

SMILES 字串

COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2

InChI

1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1

InChI 密鑰

TZJALUIVHRYQQB-XLRXWWTNSA-N

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相關類別

一般說明

淫羊藿苷是一种戊基化的黄酮醇，是淫羊藿中主要的生物活性化合物。

應用

淫羊藿苷已被用于：
  • 制备局部外用制剂，用于测定其对大鼠皮肤创面愈合的影响
  • 测试其对大鼠下背痛（LBP）的镇痛作用
  • 作为大鼠骨质疏松症的潜在疗法
  • 研究其对棕榈酸酯(PA)诱导的骨骼肌C2C12肌管中胰岛素抵抗的影响
  • 作为神经保护剂研究其对人神经母细胞瘤SK-N-MC细胞中淀粉样蛋白-β (Aβ)-诱导的神经元胰岛素抵抗的影响

生化／生理作用

淫羊藿苷是一种治疗神经退行性疾病和其他影响神经系统的疾病的有效神经保护剂。它在未受精的卵母细胞中诱导抗衰老特性，以对抗年龄相关损伤。淫羊藿苷具有抗炎和抗纤维化的特性，有助于保护慢性肾病(CKD)相关的小鼠肾纤维化模型。它还是一种很好的抗糖尿病和抗动脉粥样硬化药物。淫羊藿苷是一种有效的抗癌药物。
来源于淫羊藿属植物的黄酮类葡萄糖苷。该药理活性成分或其衍生物可促进骨形成、调节多药耐药性、增强神经元活力、刺激血管生成，并表现出抗氧化活性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
WXBD2828V
MKCJ1712
MKCG3542
MKCG2335
MKCD7860

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存取文件庫

Qian Qian et al.
Journal of pharmaceutical and biomedical analysis, 66, 392-398 (2012-04-24)
In this work, the metabolite profiles of icariin in rat plasma were qualitatively investigated, and the possible metabolic pathways of icariin were subsequently proposed. After oral administration of icariin, rat plasma samples were collected and pretreated by protein precipitation. Then
D Li et al.
Osteoarthritis and cartilage, 20(12), 1647-1656 (2012-08-25)
To investigate whether icariin, which is a widely used pharmacological constituent in traditional Chinese herbal medicine, can be a potential promoting compound for cartilage tissue engineering. Icariin was added into cell-hydrogel constructs derived from neonatal rabbit chondrocytes and collagen type
Hsin-An Chen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 59, 152917-152917 (2019-04-13)
The pathology change of renal tubulointerstitial fibrosis is a critical feature of chronic kidney disease (CKD), regardless of the primary insults. The infiltration of inflammatory cells and the consecutive secretion of profibrotic factors are frequently and conspicuously observed during the
Bin Wu et al.
Journal of ethnopharmacology, 142(3), 746-753 (2012-06-13)
Icariin represents an important active component in Herba Epimedii, which is a famous Chinese herbal medicine that is widely used to treat some age-related diseases in oriental countries. The aim of this work was to investigate the effects of icariin
Dawei Zhang et al.
Biochimie, 94(12), 2514-2522 (2012-07-17)
Accumulating evidences suggest that Herba epimedii has the potential benefits against osteoporosis. However, previous studies were focused on the crude extract, total flavonoids (TF) and icariin (ICA), and the detailed molecular mechanisms of action and structure-activity relationship (SAR) remain unclear.
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