推薦產品
產品名稱
N-乙酰-5-羟色胺, ≥99% (HPLC), powder
品質等級
化驗
≥99% (HPLC)
形狀
powder
顏色
white to faint yellow
mp
120-122 °C (lit.)
溶解度
ethanol: 50 mg/mL
儲存溫度
2-8°C
SMILES 字串
CC(=O)NCCc1c[nH]c2ccc(O)cc12
InChI
1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
InChI 密鑰
MVAWJSIDNICKHF-UHFFFAOYSA-N
基因資訊
human ... MTNR1A(4543) , MTNR1B(4544)
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一般說明
N-乙酰血清素 (NAS)（又称normelatonin）是色氨酸代谢途径中褪黑激素的前体。
應用
N-乙酰基-5-羟色胺已被用于治疗神经元细胞，并分析其对Krüppel样因子15（KLF15）表达的影响。
生化／生理作用
N-乙酰血清素（NAS，又称normelatonin）可以保护神经元，因为它能够防止氧化胁迫。 它还可以抑制转录因子NF-κB的作用。NAS具有抗氧化和抗衰老作用。它可以防止β-淀粉质引起的神经毒性。它有助于维持生物膜的最佳流动性能。
褪黑激素的直接前体。它由血清素和乙酰辅酶 A 在血清素 N-乙酰转移酶（褪黑激素生物合成中的限速酶）催化下形成的。该吲哚胺是褪黑激素受体的弱激动剂，对 G 蛋白刺激和 cAMP 积累的抑制有一定的作用。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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