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Merck
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重要文件

C9538

Sigma-Aldrich

辅酶 Q10

≥98% (HPLC), powder, antioxidant

同義詞:

CoQ10, Q-10, 辅酶Q10, 辅酶Q50

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About This Item

經驗公式(希爾表示法):
C59H90O4
CAS號碼:
分子量::
863.34
Beilstein:
1900141
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

產品名稱

辅酶 Q10, ≥98% (HPLC)

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow to dark orange

mp

49 °C

應用

cell analysis

儲存溫度

−20°C

SMILES 字串

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

InChI 密鑰

ACTIUHUUMQJHFO-UPTCCGCDSA-N

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一般說明

辅酶 Q(CoQ)又称泛醌,是一种脂溶性抗氧化剂,是线粒体电子传递链的重要组成部分。该分子含有一个生物活性醌,包含一个苯醌环和一个异戊二烯侧链。Q10在细胞质和线粒体中合成(),通过有氧细胞呼吸产生ATP。免疫系统的顺利运行和心血管健康都需要CoQ10()。抑制炎症基因表达的能力显示了它的抗炎特性()。 基因缺陷或衰老导致CoQ10缺乏,表现为免疫功能受到抑制。()

應用

辅酶Q10(CoQ10)已被用于:
  • 作为一种生物活性化合物,在体外研究其免疫调节特性
  • 高效液相色谱的标准品
  • 研究其对运动大鼠主动脉的影响
  • 细胞CoQ摄取检测

生化/生理作用

辅酶Q10是一种内源性细胞抗氧化剂,是电子传递链的重要组成部分。辅酶Q10参与有氧细胞呼吸和ATP形式的能量产生。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Courtney M Anderson et al.
Cell reports, 10(4), 505-515 (2015-01-27)
Brown adipose tissue (BAT) possesses the inherent ability to dissipate metabolic energy as heat through uncoupled mitochondrial respiration. An essential component of the mitochondrial electron transport chain is coenzyme Q (CoQ). While cells synthesize CoQ mostly endogenously, exogenous supplementation with
N Okudan et al.
Acta physiologica Hungarica, 99(1), 40-50 (2012-03-20)
In this study, the effect of long-term supplementation of coenzyme Q10 (CoQ10) on the responses of swim-trained rat aorta was investigated. Twenty-four adult male Wistar rats were divided into four groups: untrained, trained, untrained+CoQ10, and trained+CoQ10 group. In the trained
E L Appelkvist et al.
The Clinical investigator, 71(8 Suppl), S97-102 (1993-01-01)
Inhibitors of hydroxymethylglutaryl coenzyme A reductase are used clinically to decrease blood levels of low-density lipoprotein cholesterol in hypercholesterolemic patients. However, little is known about the possible effects of these inhibitors on dolichol and cholesterol synthesis. Oral administration of mevinolin
Lionel Van Maldergem et al.
Annals of neurology, 52(6), 750-754 (2002-11-26)
A 31-year-old woman had encephalopathy, growth retardation, infantilism, ataxia, deafness, lactic acidosis, and increased signals of caudate and putamen on brain magnetic resonance imaging. Muscle biochemistry showed succinate:cytochrome c oxidoreductase (complex II-III) deficiency. Both clinical and biochemical abnormalities improved remarkably
Steven Lunetta et al.
Journal of AOAC International, 91(4), 702-708 (2008-08-30)
An international collaborative study was conducted of a high-performance liquid chromatographic (HPLC)-UV method for the determination of coenzyme Q10 (CoQ10, ubidecarenone) in raw materials and dietary supplements. Ten collaborating laboratories determined the total CoQ10 content in 8 blind duplicate samples.

文章

Learn about the four membrane-bound protein complexes that make up the electron transport chain metabolic pathway supplying energy as ATP for cellular respiration.

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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